Why Peptides for Weight Loss in 2025?

Weight loss is no longer just about dieting harder or running longer. In 2025, many people—especially those struggling with stubborn fat, slow metabolism, or hormonal imbalance—are turning to a new class of compounds: peptides.

The problem? The internet is flooded with hype, half-truths, and outdated information. Whether you’re a fitness enthusiast looking for an edge, someone battling obesity, or a bio-hacker curious about the science, it’s hard to know which peptides actually work for weight loss—and which are just buzzwords.

This article cuts through the noise.

We’ve researched, compared, and ranked the 7 most effective weight loss peptides in 2025 based on clinical data, user results, and expert reviews. You’ll learn what each peptide does, how it works, who it’s best for, and what to expect in terms of results and side effects.

Whether your goal is to suppress appetite, burn belly fat, preserve muscle during cutting, or speed up metabolism—this guide will help you pick the right tool for the job.

Let’s get into it.

How We Ranked These Peptides

Not all peptides are created equal—and when it comes to fat loss, the differences matter. To create this list, we evaluated dozens of peptide compounds, clinical reports, and user experiences to identify the most effective, reliable, and accessible fat-burning peptides available in 2025.

Here’s what we considered when ranking the top 7:

1. Clinical Effectiveness

The most important factor: does it work?

We prioritized peptides with strong clinical evidence supporting their fat loss effects—especially those backed by:

  • Randomized controlled trials
  • Meta-analyses
  • FDA approvals or ongoing medical use

The higher the average fat loss, the higher the rank.

2. Mechanism of Action

Peptides that trigger multiple fat loss pathways (e.g., appetite suppression and metabolic enhancement) scored higher. We also considered:

  • Hormonal balance support
  • Blood sugar regulation
  • Lipolysis stimulation
  • Muscle-sparing effects

3. Safety and Side Effects

No one wants fast results with long-term consequences. We favored peptides with:

  • Mild or manageable side effects
  • No severe long-term risks (based on current data)
  • Good tolerance in diverse populations

Bonus points for those with non-hormonal mechanisms.

4. Real-World Popularity

Beyond the lab, we analyzed how widely each peptide is used in:

  • Medical weight loss clinics
  • TRT and bio-hacking communities
  • Fitness and bodybuilding circles

This helped us identify what’s actually working for real people in 2025—not just in clinical settings.

5. Accessibility & Legality

A great peptide isn’t helpful if no one can access it.

We considered:

  • Whether it’s legally prescribed or available through compounding
  • Cost and availability (online or in clinics)
  • Ease of use (e.g., weekly injections vs. daily)

Peptides that are widely available and easy to administer ranked higher.

6. Sustainability & Long-Term Value

Lastly, we looked at how these peptides fit into a long-term fat loss strategy:

  • Can they be cycled or used long-term?
  • Do users keep the weight off?
  • Is there risk of rebound after stopping?

Peptides that support lasting results were prioritized.

This multi-factor scoring system helped us spotlight the 7 most promising and effective peptides for weight loss in 2025—ranked not just by hype, but by science, safety, and success.

#1 Tirzepatide – The All-Around Fat Loss King

Tirzepatide has taken the weight loss world by storm—and for good reason. Originally developed for type 2 diabetes, this dual-action peptide quickly gained popularity for its dramatic fat-burning effects. In 2025, it remains the most powerful, clinically backed peptide for significant and sustained weight reduction.

What is Tirzepatide?

Tirzepatide is a dual GIP and GLP-1 receptor agonist. That means it mimics two key gut hormones that regulate blood sugar, insulin response, and appetite control. By activating these pathways, it helps your body:

  • Reduce food cravings
  • Improve insulin sensitivity
  • Delay gastric emptying (so you feel full longer)
  • Burn fat more efficiently

Marketed under brand names like Mounjaro® and Zepbound®, it has become a go-to for doctors, weight loss clinics, and athletes aiming to drop fat without crashing their metabolism.

Why It’s Ranked #1

  • Highest fat loss results in clinical trials
  • Dual-action mechanism (GLP-1 + GIP = more powerful than Semaglutide)
  • FDA-approved and widely available
  • Consistent results across obese, overweight, and type 2 diabetic populations

In head-to-head studies, Tirzepatide outperformed Semaglutide in both weight loss and metabolic improvement. Some participants lost 20% or more of their body weight in less than 18 months.

How It Works

MechanismEffect
GLP-1 ActivationSuppresses appetite, stabilizes blood sugar
GIP ActivationEnhances insulin sensitivity, supports fat burning
Delayed Gastric EmptyingMakes you feel fuller longer
Insulin RegulationPrevents energy crashes and fat storage

Together, these effects create the ideal hormonal environment for fat loss, even in people who’ve failed on traditional diets.

Dosing Protocol (Typical Clinical Use)

  • Starting dose: 2.5 mg weekly
  • Titration: Increase by 2.5 mg every 4 weeks
  • Max dose: 15 mg weekly (based on tolerance and goals)
  • Injection type: Subcutaneous, once per week

Always consult a medical provider before starting, as individual tolerances vary.

Pros

  • Clinically proven for significant weight loss
  • Helps regulate blood sugar and insulin
  • Weekly injections = convenient dosing
  • Strong appetite suppression
  • Often improves energy, sleep, and mood

Cons

  • Can cause nausea or GI discomfort during titration
  • May be expensive or require prescription
  • Not ideal for extremely lean individuals or those bulking

Best For:

  • Overweight and obese individuals
  • People with insulin resistance or metabolic syndrome
  • Anyone seeking dramatic, consistent fat loss

Key Study Highlight

A 2022 NEJM study showed that participants on the highest dose of Tirzepatide lost 22.5% of body weight on average over 72 weeks—outperforming all existing weight loss medications at the time.

In short, Tirzepatide is the current gold standard for peptide-assisted weight loss in 2025. If you’re looking for a compound that delivers major results with minimal guesswork, this is the one to watch.

#2 Semaglutide – Clinically Proven, Widely Available

Semaglutide became a household name after its breakthrough success under the brand names Ozempic and Wegovy. Originally developed as a treatment for type 2 diabetes, it has since proven to be one of the most effective medical interventions for weight loss available today.

In 2025, Semaglutide continues to dominate the peptide-assisted fat loss space due to its impressive clinical results, wide availability, and strong safety record. It’s especially popular among those who want medically supervised, steady, and sustainable fat loss without resorting to extreme measures.

What is Semaglutide?

Semaglutide is a GLP-1 receptor agonist. It mimics a natural hormone called glucagon-like peptide-1, which helps regulate blood sugar, insulin secretion, and appetite. By stimulating the GLP-1 receptor, Semaglutide helps users:

  • Feel full faster and longer
  • Reduce cravings and emotional eating
  • Lower blood glucose and insulin resistance
  • Burn fat more efficiently

This mechanism allows Semaglutide to function as both a metabolic enhancer and an appetite suppressant—two key pillars of effective weight loss.

Why It’s Ranked #2

  • Backed by extensive clinical trials and FDA approval
  • Effective across different weight categories, from overweight to obese
  • Widely used in both medical and aesthetic settings
  • Weekly dosing for convenience

Semaglutide might rank just behind Tirzepatide due to its single-pathway (GLP-1 only) mechanism, but its accessibility, proven results, and wide medical adoption keep it high on the list.

How It Works

Mechanism Effect
GLP-1 Receptor Activation Reduces hunger and calorie intake
Delayed Gastric Emptying Prolongs feelings of fullness
Improved Insulin Sensitivity Enhances fat burning and energy regulation

Dosing Protocol (General Guidelines)

  • Starting dose: 0.25 mg per week
  • Titration: Increase every 4 weeks based on tolerance
  • Typical effective dose: 1.0 to 2.4 mg per week
  • Administration: Subcutaneous injection, once weekly

Note: Always consult a qualified medical provider before starting, as individual response and tolerance level may vary.

Pros

  • Clinically proven for significant weight loss
  • Well-tolerated by most users
  • Reduces appetite and cravings
  • Convenient weekly injections
  • Supports cardiovascular and metabolic health

Cons

  • May cause nausea, bloating, or mild GI discomfort
  • Requires gradual dose escalation
  • Weight loss may plateau over time without diet changes
  • Prescription required in many countries

Best For

  • Individuals with a BMI over 25
  • People struggling with portion control or constant hunger
  • Those who prefer medically guided weight loss plans

Key Study Highlight

In a 2021 clinical trial published in the New England Journal of Medicine, participants taking 2.4 mg of Semaglutide weekly lost an average of 14.9% of their body weight over 68 weeks—more than triple the placebo group.

In summary, Semaglutide offers one of the most proven, practical, and sustainable approaches to fat loss in 2025. While it’s slightly less powerful than Tirzepatide, its widespread use and established safety profile make it an excellent choice for many.

#3 CJC-1295 + Ipamorelin – Fat Loss + Muscle Retention

CJC-1295 + Ipamorelin is a powerful peptide combo known for stimulating natural growth hormone (GH) release. While it doesn’t suppress appetite like GLP-1 agonists, it offers a unique fat loss approach by increasing metabolism, improving recovery, and preserving lean muscle mass—making it ideal for athletes, bodybuilders, and those on a cutting phase.

This combination remains one of the most effective non-stimulant fat burners in 2025, and it’s especially popular in the fitness and anti-aging community for its dual benefits of fat reduction and muscle preservation.

What Are CJC-1295 and Ipamorelin?

CJC-1295 is a growth hormone-releasing hormone (GHRH) analogue, while Ipamorelin is a growth hormone-releasing peptide (GHRP). When used together, they mimic the body’s natural GH pulse to stimulate the pituitary gland and increase endogenous growth hormone production.

The result: more fat is mobilized for energy, lean mass is protected, and recovery is enhanced—all without the use of synthetic HGH.

Why It’s Ranked #3

  • Increases natural GH and IGF-1 levels
  • Helps burn fat while preserving muscle
  • Supports deep sleep, recovery, and anti-aging
  • Low risk of side effects when properly dosed

It ranks below Tirzepatide and Semaglutide only because it requires daily injections and doesn’t offer strong appetite suppression. However, for body recomposition, it’s a standout performer.

How It Works

Peptide Primary Function
CJC-1295 Stimulates sustained GH release (long-acting)
Ipamorelin Triggers GH pulses without cortisol or prolactin spikes
Combined Effect Increased fat metabolism, better recovery, enhanced sleep

Dosing Protocol (Typical Use)

  • CJC-1295 DAC: 1-2 mg, 1–2 times per week
  • Ipamorelin: 100–300 mcg, 1–3 times daily
  • Administration: Subcutaneous injection
  • Best taken before bed or post-workout

Note: Some users combine non-DAC CJC-1295 with Ipamorelin for daily injections, while others prefer DAC (Drug Affinity Complex) versions for weekly convenience.

Pros

  • Promotes fat loss without muscle loss
  • Improves deep sleep and recovery
  • Boosts natural growth hormone production
  • No significant appetite suppression required
  • Low side effect profile compared to synthetic HGH

Cons

  • Requires frequent injections for best results
  • Slower fat loss compared to GLP-1 peptides
  • More effective when paired with proper diet and training
  • Not ideal for sedentary users seeking rapid weight loss

Best For

  • Fitness enthusiasts and athletes during a cutting phase
  • Bodybuilders seeking fat loss without losing muscle
  • Anyone interested in longevity or performance optimization

Key Study Highlight

Research published in the journal Growth Hormone & IGF Research noted that consistent GH secretagogue use (like CJC-1295 + Ipamorelin) resulted in improved fat oxidation and lean body mass preservation in overweight subjects over a 12-week period.

In summary, if you’re looking to drop fat without sacrificing hard-earned muscle, CJC-1295 and Ipamorelin is one of the smartest peptide stacks available today.

#4 Tesamorelin – Visceral Fat’s Worst Enemy

Tesamorelin is one of the most targeted peptides available for reducing visceral fat—the dangerous kind that wraps around internal organs. Originally developed and approved to treat lipodystrophy in HIV patients, Tesamorelin has become increasingly popular in both medical and performance-focused circles for its ability to shrink abdominal fat stores while maintaining lean muscle.

In 2025, it’s earning recognition not just as a niche prescription drug, but as a precision fat loss peptide for men and women with stubborn belly fat or metabolic resistance.

What is Tesamorelin?

Tesamorelin is a synthetic peptide that acts as a growth hormone-releasing hormone (GHRH) analogue. It stimulates the pituitary gland to produce more natural growth hormone (GH), which in turn helps regulate fat metabolism, protein synthesis, and cellular repair.

What makes Tesamorelin unique is its clinically documented ability to reduce visceral adipose tissue (VAT) without causing significant side effects related to water retention, insulin resistance, or abnormal IGF-1 spikes.

Why It’s Ranked #4

  • Targets visceral fat specifically
  • Clinically approved and extensively studied
  • Supports lean body mass during fat loss
  • Fewer metabolic side effects than traditional HGH use

It ranks just below CJC-1295 + Ipamorelin due to its prescription-only status and narrower application. However, for those dealing with belly fat or metabolic syndrome, it’s one of the most precise tools available.

How It Works

Mechanism Effect
Stimulates GHRH Receptors Triggers pulsatile GH release
Increases IGF-1 Production Supports muscle retention and tissue repair
Reduces Visceral Fat Storage Improves waistline, insulin sensitivity, and liver health

Dosing Protocol (Standard Use)

  • Typical dose: 2 mg daily
  • Injection type: Subcutaneous, ideally before bedtime
  • Cycle length: 8–16 weeks for optimal results

Tesamorelin is most effective when combined with a mild caloric deficit and light resistance training. It’s not a magic bullet but delivers targeted results over time.

Pros

  • Clinically proven to reduce abdominal visceral fat
  • Preserves lean muscle mass
  • Improves markers of metabolic health (insulin, cholesterol, liver fat)
  • Minimal water retention or bloating

Cons

  • Prescription-only in most countries
  • May take several weeks to show visible results
  • Not effective for general body fat reduction
  • Moderately expensive

Best For

  • Men and women with stubborn belly fat
  • People with insulin resistance or fatty liver issues
  • Bio-hackers and aging adults aiming to reduce VAT risk

Key Study Highlight

In a controlled trial published in the journal JAMA, Tesamorelin reduced visceral fat by 15–20% in just 12 weeks among HIV patients with lipodystrophy. Improvements in triglycerides, insulin resistance, and liver function were also recorded.

For anyone battling deep abdominal fat, especially those over 35, Tesamorelin is a medically backed solution that goes beyond superficial fat loss. It’s a tool for long-term health as much as for body composition.

#5 AOD-9604 – Fast, Targeted Fat Burning

AOD-9604 is a modified fragment of human growth hormone (HGH) designed specifically to stimulate fat loss without the side effects of full-length HGH. Often referred to as the “fat-burning fragment,” AOD-9604 has gained popularity as a non-hormonal, targeted approach to weight reduction—especially in individuals who want to avoid altering their hormone levels.

Unlike traditional growth hormone therapies, AOD-9604 does not affect blood sugar or IGF-1 levels, making it a safer option for many users, including older adults and those with metabolic concerns.

What is AOD-9604?

AOD-9604 is a synthetic peptide derived from the C-terminal end of the HGH molecule (fragment 176–191). This small sequence retains the fat-burning properties of HGH while eliminating its growth-promoting and insulin-modulating effects.

It works by directly stimulating the breakdown of stored fat and preventing the formation of new fat deposits, particularly in stubborn areas like the abdomen and thighs.

Why It’s Ranked #5

  • Targets fat loss specifically, with no impact on muscle or hormones
  • Minimal to no side effects reported
  • Available in both injectable and oral forms
  • Ideal for general weight loss or aesthetic goals

While not as powerful as GLP-1 or GH-releasing peptides, AOD-9604 earns its place for its targeted mechanism and excellent safety profile.

How It Works

Mechanism Effect
Stimulates Lipolysis Promotes breakdown of stored fat for energy
Inhibits Lipogenesis Prevents formation of new fat cells
No GH or IGF-1 Interaction Minimises risk of hormonal imbalance

Dosing Protocol (Typical Use)

  • Standard dose: 300–500 mcg per day
  • Administration: Subcutaneous injection or oral tablet
  • Cycle length: 6–12 weeks
  • Best taken in the morning or before physical activity

Oral AOD-9604 is convenient but may be less effective than injectable versions for some users. Consistency is key.

Pros

  • Non-hormonal and safe for long-term use
  • Specifically targets fat loss without muscle impact
  • No effect on blood sugar, cortisol, or IGF-1
  • Minimal to no reported side effects
  • Can be stacked with other peptides

Cons

  • Fat loss is moderate and gradual
  • Less effective on its own without diet or exercise
  • Results vary depending on body composition
  • Not ideal for advanced athletes or cutting cycles

Best For

  • Beginners looking for a mild fat-burning aid
  • Those avoiding hormonal or appetite-affecting peptides
  • Users focused on aesthetic improvements (waist, hips, thighs)

Key Study Highlight

A randomized trial published in Obesity Research & Clinical Practice found that AOD-9604 significantly reduced body fat in overweight adults over a 12 week period, with no adverse effects on blood sugar, IGF-1, or cardiovascular markers.

In summary, AOD 9604 offers a low-risk, targeted fat-loss solution for those who want visible results without hormonal intervention. While it may not deliver rapid transformation, its safety and versatility make it an attractive option in 2025.

#6 5-Amino-1MQ – Boost Your Basal Metabolism

5-Amino-1MQ is a small molecule compound that has made its way into peptide discussions due to its powerful metabolic benefits. While technically not a peptide, it’s frequently grouped with them because of its bio-hacking popularity and use in body recomposition protocols. Its primary benefit? Revving up your metabolic engine at the cellular level.

5-Amino-1MQ works by targeting an enzyme called NNMT (nicotinamide N-methyltransferase), which is linked to fat cell function, insulin sensitivity, and metabolic slowdown. By inhibiting NNMT, 5-Amino-1MQ supports increased energy expenditure, fat oxidation, and cellular repair.

What is 5-Amino-1MQ?

5-Amino-1MQ is a molecule that inhibits NNMT, an enzyme associated with reduced NAD+ levels and increased fat storage. By blocking NNMT, this compound helps to increase NAD+ activity, which improves mitochondrial function, energy output, and metabolism.

Although not a peptide, it’s widely used by fitness enthusiasts, anti-aging clinics, and those looking for a non-injectable alternative to boost fat loss and performance.

Why It’s Ranked #6

  • Enhances fat metabolism via NAD+ pathways
  • Oral, non-hormonal, and easy to use
  • Promising results in animal and early human trials
  • Popular among longevity and biohacking communities

5-Amino-1MQ ranks just below AOD-9604 due to limited clinical studies and anecdotal variability. However, its unique mechanism and oral format make it highly appealing.

How It Works

Mechanism Effect
NNMT Inhibition Increases NAD+ availability, boosts metabolism
Fat Cell Modulation Reduces size and number of white fat cells
Cellular Energy Optimization Improves mitochondrial function and fat oxidation

Dosing Protocol (Typical Use)

  • Common dose: 50–150 mg per day (oral capsule)
  • Cycle length: 4–8 weeks with breaks
  • Stacking: Often paired with GLP-1 agonists or AOD-9604

Most users report increased energy, better focus, and mild fat loss, especially when combined with calorie control or exercise.

Pros

  • Non-peptide, easy-to-use oral supplement
  • Targets fat loss through metabolic enhancement
  • No hormonal impact or appetite suppression needed
  • May boost cognitive and physical performance

Cons

  • Limited human research to date
  • Effects may be subtle without exercise or diet support
  • Not suitable as a standalone solution for obesity
  • Quality can vary depending on the source

Best For

  • Bio-hackers and performance-focused individuals
  • People seeking oral fat-loss solutions
  • Anyone looking to boost resting metabolic rate

Key Study Highlight

In animal studies, 5-Amino-1MQ supplementation resulted in a reduction of white fat mass and improved insulin sensitivity, without affecting lean tissue or appetite. Early human feedback has shown promising trends in fat loss and energy enhancement.

For those who want a metabolism-focused, easy-to-use fat loss enhancer without injections or hormone manipulation, 5-Amino-1MQ is a promising option to watch in 2025.

#7 Amlexanox – The Inflammation-Fat Loss Connection

Amlexanox is a surprising entry in the fat loss peptide space. Originally developed as an anti-inflammatory drug for asthma and canker sores, it has gained attention for its ability to target the root causes of metabolic slowdown, particularly in individuals struggling with chronic inflammation and insulin resistance.

Amlexanox doesn’t suppress appetite or stimulate growth hormone. Instead, it works at the cellular level to improve insulin sensitivity and reprogram fat cells—especially in those whose weight loss has plateaued due to inflammation or metabolic dysfunction.

What is Amlexanox?

Amlexanox is a small molecule that inhibits IKK-ε and TBK1, two enzymes known to promote inflammation and interfere with fat metabolism. These enzymes become overactive in obese individuals, leading to chronic low-grade inflammation and reduced energy expenditure.

By turning off these enzymes, Amlexanox restores fat cell responsiveness, increases energy use, and supports sustainable fat loss—even without major dietary changes.

Why It’s Ranked #7

  • Targets inflammation-related weight gain
  • Improves insulin sensitivity and mitochondrial function
  • Ideal for metabolically resistant individuals
  • Well tolerated in early human studies

Amlexanox earns the #7 spot due to its unique mechanism and promising data, especially for users with stubborn fat or metabolic syndrome. It’s not as fast-acting as GLP-1 agonists but fills an important gap.

How It Works

Mechanism Effect
IKK-ε / TBK1 Inhibition Reduces inflammation in fat cells
Improved Insulin Response Restores metabolic flexibility
Increased Energy Expenditure Burns more calories at rest

Dosing Protocol (Emerging Use)

  • Typical dose: 25–100 mg daily (oral capsule)
  • Cycle length: 4–12 weeks
  • Stacking: Often combined with GLP-1 or AOD-9604 for enhanced effect

Although not yet widely prescribed, Amlexanox is increasingly available via compounding pharmacies and experimental protocols in obesity clinics.

Pros

  • Targets inflammation and metabolic dysfunction directly
  • Improves insulin sensitivity and blood glucose regulation
  • Non-hormonal and orally dosed
  • Promotes sustainable fat loss in resistant cases

Cons

  • Not a fast-acting fat burner
  • Limited availability and clinical use
  • Still under research for long-term effects
  • Best suited for individuals with inflammation-related weight issues

Best For

  • Individuals with metabolic syndrome or type 2 diabetes
  • People who plateau on standard fat loss methods
  • Those with chronic inflammation or insulin resistance

Key Study Highlight

A 2013 study in Nature Medicine found that Amlexanox increased energy expenditure, improved insulin sensitivity, and reduced fat mass in obese mice. Early human studies have shown similar trends, with minimal side effects.

Amlexanox is not your typical fat loss peptide, but for those dealing with inflammation-fueled weight gain or insulin resistance, it’s a scientifically grounded option worth exploring in 2025.

Comparison Table: Top 7 Peptides for Weight Loss in 2025

Peptide Main Mechanism Best For Administration Strength Notable Drawback
Tirzepatide Dual GLP-1 + GIP agonist (appetite & insulin) Significant fat loss & metabolic reset Weekly injection ★★★★★ Initial GI discomfort, prescription only
Semaglutide GLP-1 receptor agonist (appetite control) Steady, clinical-grade weight loss Weekly injection ★★★★☆ Plateau risk, slower onset
CJC-1295 + Ipamorelin Growth hormone stimulation (GH + IGF-1) Fat loss with muscle retention Daily or weekly injections ★★★★☆ More frequent dosing, slower fat loss
Tesamorelin GHRH analogue targeting visceral fat Belly fat, metabolic syndrome Daily injection ★★★★☆ Prescription required, slower onset
AOD-9604 Fat-burning fragment of HGH General weight loss, aesthetics Injection or oral ★★★☆☆ Mild effects, gradual results
5-Amino-1MQ NNMT inhibition (cellular metabolism boost) Basal metabolic rate, energy Oral capsule ★★★☆☆ Limited human data
Amlexanox Anti-inflammatory enzyme blocker Plateaued or insulin-resistant users Oral capsule ★★★☆☆ Slow onset, niche use case

3 Other Peptides Worth Mentioning

While the top 7 peptides cover the most effective and widely used options in 2025, these three additional peptides have shown promising fat loss benefits and are worth keeping an eye on as research and availability evolve.

1. BPC-157

BPC-157 is primarily known for its powerful healing and recovery effects, but many users report improved metabolism and fat loss indirectly through enhanced exercise recovery and reduced inflammation. It’s an excellent adjunct for those combining peptides with a solid fitness regimen.

2. TB-500 (Thymosin Beta-4)

TB-500 aids tissue repair and inflammation reduction. While not a direct fat burner, its ability to speed recovery and reduce injury downtime can help maintain consistent training and promote fat loss over time.

3. MK-677 (Ibutamoren)

MK-677 is a growth hormone secretagogue that increases GH and IGF-1 levels orally. Although it may cause some water retention, it supports fat metabolism and muscle preservation, making it popular for long-term body recomposition.

In 2025, peptides continue to revolutionize weight loss strategies by offering targeted, effective, and science-backed solutions for fat reduction and metabolic health. From clinically proven options like Tirzepatide and Semaglutide to innovative metabolic enhancers such as 5-Amino-1MQ and Amlexanox, this comprehensive ranking highlights peptides tailored for different goals and body types. Whether you seek appetite suppression, visceral fat reduction, or muscle preservation, incorporating these peptides alongside proper nutrition and exercise can help accelerate and sustain your weight loss journey safely and efficiently.

References